Influence of Age on Patterns of Uptake and Excretion of Polycyclic Aromatic Hydrocarbons in the Rainbow Trout Embryo

RM Kocan; RG Stahl

doi:10.1520/STP29033S

SYMPOSIA PAPER Published: 01 January 1986

STP29033S

Influence of Age on Patterns of Uptake and Excretion of Polycyclic Aromatic Hydrocarbons in the Rainbow Trout Embryo

Source

An investigation of the uptake, metabolism, and excretion of benzo(a)pyrene (B(a)P) and its metabolites in developing rainbow trout embryos and larvae, as well as the effects of mixed function oxygenase (MFO) inducers on these processes, has been conducted. The time of exposure during development has a significant effect on the rate of uptake and excretion, and MFO inducers can significantly influence the rate of excretion of the metabolites. In addition, the appearance of measurable B(a)P monooxygenase activity is related to the embryo's developmental stage, and embryonic trout metabolize B(a)P to compounds similar to those produced by adult fish and mammals.

Author Information

Stahl, RG

The University of Washington, Seattle, WA Central Research and Development Department, E. I. du Pont de Nemours & Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE

Kocan, RM

The University of Washington, Seattle, WA

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Details

Developed by Committee: E47

Pages: 287–303

DOI: 10.1520/STP29033S

ISBN-EB: 978-0-8031-4986-1

ISBN-13: 978-0-8031-0489-1

Influence of Age on Patterns of Uptake and Excretion of Polycyclic Aromatic Hydrocarbons in the Rainbow Trout Embryo

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