SYMPOSIA PAPER Published: 01 April 2025
STP165220230022

High-Throughput Screening of Coformulants for Rapid Assessment of Biocompatibility with Gram-Positive and Gram-Negative Bacteria in Biopesticide Formulations

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The recent growth of the global biopesticide market has been driven by the increasing demand for environmentally friendly and sustainable alternatives to synthetic pesticides in agriculture. In 2021, the market reached a value of $5.4 billion and is projected to reach $12.1 billion by 2027. As a result, companies are acquiring biotech firms to gain access to their technologies and expertise in biopesticides. In addition to the challenges faced in the development of synthetic pesticides, the effectiveness of microbes in biopesticide formulations can be influenced by the choice of coformulants. This study utilizes a high-throughput screening technique to investigate the compatibility of four gram-positive and one gram-negative bacteria with commonly used coformulants found in pesticide formulations. By varying the concentrations of these coformulants, we could assess the viability of the microbes, and the inhibitory concentrations 50 and 90 (IC50 and MIC90) values were determined to measure the level of inhibition observed. Consistency in compatibility levels was observed among bacteria within the same genus, while certain coformulants exhibited contrasting behavior within the same bacterial genus. This observation emphasizes the importance of using a rapid testing methodology for evaluating microbial compatibility.

Author Information

Bhowmik, Bijit, K.
Croda Inc., New Castle, DE, US
Vitorazzi de Castro, Nathan
Croda Inc., New Castle, DE, US
Dempsey, Logan, P.
Croda Inc., New Castle, DE, US
Sun, J., Susan
Croda Inc., New Castle, DE, US
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Pages: 47–64
DOI: 10.1520/STP165220230022
ISBN-EB: 978-0-8031-7752-9
ISBN-13: 978-0-8031-7751-2