A new technological process of manufacturing ingots for fuel rod claddings made of the electrolytic zirconium-based E110 alloy, which guarantees the removal of residual fluorine impurities in the ingot to less than the 1 ppm level, has been developed in order to ensure claddings' resistance to breakaway oxidation in high-temperature steam. The new technological process involves using electron beam melting by optimized modes as the first melting of the ingot and then at least two optimized vacuum arc melts. Pilot tubes for fuel rod claddings made of such ingots are not susceptible to breakaway oxidation in steam at a temperature of 1,000°C for 5,000 s to the oxidation state of 24% equivalent cladding reacted samples, which is similar to the behavior of fuel rod claddings made of the E110 alloy based on zirconium sponge and that meets the relevant safety criterion of a loss-of-collant design accident.