The link between the results of small- (curved compact) and large-scale (burst) toughness tests on irradiated Zr-2.5Nb pressure tube material was investigated using material from tubes of different toughness values. Comparison between the crack growth resistance (deformation J-R) curves from the small- and large-scale specimens reveals the material dependence of geometry effects and shows that the crack-tip constraint in the compact specimen is generally higher than that in the burst specimen. For higher toughness material, the crack-extension region over which there is good correspondence between the J-R curves from the small- and large-scale specimens is in agreement with current knowledge of validity requirements for J-controlled crack growth of bend-type specimens. Fractographic studies were conducted and the results shown to be consistent with the observed geometry effects, a larger proportion of highly constrained, flat fracture being produced with the small bend-type specimens than with the burst tests. The results are discussed using a volume-controlled fracture model for bend-type specimens in which it is assumed that the toughness is governed by the development of the plastic zone associated with an intermediate-constraint, transition region between the central, flat-fracture zone and surfaceshear or slant-fracture zone. Applying scaling factors from the volume-controlled fracture model, good agreement is obtained between scaled values of the maximum pressure/load toughness from the small- and large-scale tests over a range of normalized plastic zone size of 0.4 to 1.