Green building practices, net-zero targets for buildings, and new energy codes for buildings around the world are creating demands for high-performance thermal insulation materials. Aerogel blanket is a high-performance thermal insulation having thermal resistance two to three times higher than traditional thermal insulation materials. Aerogel in blanket form is an extremely convenient material for building envelope constructions and can be cut to any reasonable size or shape. The blanket is usually available in a 10-mm thickness and can be applied, if necessary, in multiple layers. This paper assesses the implications of added aerogel thermal insulation in three different wall systems (commercial, residential, and heritage) on their moisture management performance. The hygrothermal simulation tool WUFI^® Pro 5.3 was used to carry out more than 50 simulations in five different locations (Wilmington, NC; Vancouver, BC; Minneapolis, MN; Chicago, IL; and Baltimore, MD) in North America. Simulation results demonstrate that appropriate design and construction techniques can successfully integrate aerogel blanket insulation in energy-efficient commercial, residential, and heritage wall constrictions without compromising long-term performance or durability caused by poor moisture management.