Manufacturers need to be resilient to effectively mitigate substantial disruptions to manufacturing operations so they may remain competitive. Disruptions resulting from the coronavirus disease (COVID-19) global pandemic have caused manufacturers to experience new challenges, including (1) working with reduced in-person operations, (2) retasking workers into new roles, and (3) reconfiguring their equipment and processes to yield completely new product lines. Improved monitoring, diagnostic, and prognostic technologies and methods (collectively known as prognostics and health management [PHM]) can help address these challenges and potential future disruptions.