MONOGRAPH Published: 08 December 2014
MONO62013003009

Chapter 9 | Chapter 9 | Synthetic Biomimetic Porous Polymer Scaffolds for Bone Regeneration

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Bone tissue engineering provides a promising solution to the limitations of current bone-grafting therapies. Scaffolds, serving as artificially designed temporary extracellular matrices (ECM), play a key role in bone regeneration. Synthetic biodegradable polymers can be produced under laboratory-controlled conditions to generate chemical versatility and physical features to impart advantageous properties to scaffolds. This chapter reviews the recent advances in polymer scaffolds for bone regeneration. In addition to serving as an anatomical template for the lost bone tissue, a scaffold is increasingly considered to provide the three-dimensional (3D) microenvironments for cell adhesion, proliferation, differentiation, and tissue regeneration. A biomimetic strategy is now widely accepted in bone tissue-engineering scaffold design to mimic the important features of the natural ECM and to activate the key signaling events in bone regeneration. The concepts and the fabrication processes of several important types of biomimetic scaffolds are reviewed. Scaffolds with controlled biomolecule delivery capacity are also reviewed. At the end, the current limitations and future perspectives of scaffolds for bone regeneration are discussed.

Author Information

Dang, Ming
Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI, US
Shin, Jae, Min
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, US
Ma, Peter, X.
Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI, US Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, US Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, US Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI, US
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Developed by Committee: F04
Pages: 195–217
DOI: 10.1520/MONO62013003009
ISBN-EB: 978-0-8031-7061-2
ISBN-13: 978-0-8031-7060-5