MONOGRAPH Published: 08 December 2014
MONO62013002412

Chapter 12 | Nanoscale Technologies for Bone Grafting

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Currently, total hip and knee replacements have revision rates of approximately 6 % after 5 years and 12 % after 10 years. However, these statistics do not account for the additional overwhelming lack of return to a normal active daily lifestyle after receiving such implants. Although patients do feel decreased pain in the long term after receiving such implants, those most physically active are not able to return to the active lifestyle they had before the event that led to the need to receive an implant. The related complications mainly result from implant loosening, infection, inflammation, and unmatched mechanical properties between the implant and juxtaposed bone leading to stress and strain imbalances. Recent advances in nanotechnology have provided the answers to the persistent problems seen with orthopedic implant failure. This chapter will cover recent advances in fabricating and using nanostructured metals, ceramics, and polymers for numerous orthopedic applications and discuss future research that is needed for the field to progress.

Author Information

Sun, Linlin
Bioengineering Program and Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, US
Ni, Siyu
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, CN
Webster, Thomas, J.
Bioengineering Program and Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, US
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Developed by Committee: F04
Pages: 273–286
DOI: 10.1520/MONO62013002412
ISBN-EB: 978-0-8031-7061-2
ISBN-13: 978-0-8031-7060-5