MONOGRAPH Published: 08 December 2014
MONO62013002214

Chapter 14 | Strategies toward Engineering Vascularized Bone Graft Substitutes

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The main challenge for bone tissue engineering is the vascularization of bone graft substitutes. Thus, the variability in the sizes and extent of bone injury has presented the need to repair large and small vascular networks using premade vascular structures and vascular-inducing structures. The key now for future bone substitute design depends on the combination of graded grafts that mimic the bone architecture with large vessels that can perfuse blood into the microvasculature inside of the graft. This chapter explores in detail the current options for the development of vascularized bone substitutes, the research into producing these devices, and future outlooks.

Author Information

Mercado-Pagán, Ángel, E.
Department of Orthopedic Surgery, Stanford University, Stanford, CA, US
Yang, Yunzhi, Peter
Department of Orthopedic Surgery, Stanford University, Stanford, CA, US Department of Materials Science and Engineering, Stanford University, Stanford, CA, US
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Developed by Committee: F04
Pages: 299–332
DOI: 10.1520/MONO62013002214
ISBN-EB: 978-0-8031-7061-2
ISBN-13: 978-0-8031-7060-5