Fuel corrosion often leads to various distress on bitumen concrete pavement, including particle falling, cracks, and even potholes, which will significantly shorten the service life of highways. In this study, the effects of fuel corrosion, including diesel and gasoline, on mass loss and the physical properties of styrene-butadiene-styrene (SBS) modified bitumen were investigated. Then, the influence of fuel corrosion on the anti-stripping performance of SBS-modified bitumen mixture was studied using the improved Cantabro test. Subsequently, the effects of fuel corrosion on the road performance of bitumen mixture were systematically explored. The experimental results indicate that the mass loss of SBS-modified bitumen is 85∼90 % for gasoline corrosion and 10∼20 % for diesel corrosion, and the high-temperature deformation resistance of SBS-modified bitumen is greatly weakened by fuel corrosion. Moreover, different performances, including water stability and high and low-temperature performance, are reduced in varying degrees for SBS-modified bitumen mixtures after fuel corrosion; meanwhile, the impact of gasoline is more significant than that of diesel, and the relevant research findings will provide theoretical guidance for the prevention and control of fuel corrosion on bitumen pavement.