An Expression of Concern was added to this paper in October 2025. The Expression of Concern can be found here: doi.org/10.1520/JTE20259994. The attenuation coefficient is an important parameter to describe the penetration of photons in biological materials, such as vitamins. In this study, a novel simulation model based on the Monte Carlo simulation has been utilized to calculate the mass attenuation coefficients for some vitamins at the energies 356.61, 661.66, 1,250, and 1,408.01 keV. The calculated attenuation coefficient values were then used to determine the mass energy absorption coefficient. It was observed that the parameters were highly in accordance with the XCOM program and experimental data. The results showed that the model is quite convenient in the calculation of mass attenuation coefficients. Besides, the Monte Carlo simulation can be followed to determine the attenuation of photons in various materials. The results of the investigated data are useful in the medical field.