The second, expanded edition of this single-authored treatise was written to serve geneticists who have limited statistical training and for statisticians who have been asked to apply quantitative methods to the rapid advances in fields such as molecular, population and evolutionary genetics, genomic mapping, sequencing and linkage analyses and forensic sciences. The paperback book is also a shelf reference and serves as a simple and useful review of concepts and applications. The book appears to be well-edited and without errors of notation, logic or typography because the prepublished material was already extensively reviewed by experts, and the author's students.