The assessment of strain in rock masses holds critical significance for slope stability investigations. In this context, the applicability of foil strain gauges for long-term monitoring in natural conditions has been investigated. A laboratory-based experiment was conducted in a climate chamber to evaluate whether deformation of metals and rock samples can be reliably measured under conditions analogous to those in the field. Systematic errors in ¼ bridge strain gauge configurations induced by temperature variations in rock samples with varying degrees of weathering were assessed. The objective was to employ resistive strain gauges in the current configuration to measure surface strain under natural thermal fluctuations and ascertain how results are influenced. Thus, values measured with a strain gauge fixed to the material (steel, granite with variable weathering, and aluminum) were registered. Strain responses to temperature changes reflected the different expansion of reference materials such as steel and aluminum, combined with the effect of temperature-induced drift and random errors of measurement. A methodology was developed and applied to reduce the effect of temperature-induced drift to assess the amplitude of deformation and to analyze outcomes for each rock sample undergoing weathering. This work contributes to the development of sensor solutions for real-time long-term monitoring.