Standard Test Method for Conducting a 90-Day Oral Toxicity Study in Rats (Withdrawn 2010)
Standard Test Method for Conducting a 90-Day Oral Toxicity Study in Rats (Withdrawn 2010)E1372-95R03ASTM|E1372-95R03|en-USStandard Test Method for Conducting a 90-Day Oral Toxicity Study in Rats (Withdrawn 2010)StandardE1372 Standard Test Method for Conducting a 90-Day Oral Toxicity Study in Rats (Withdrawn 2010)>newBOS Vol. 11.06 Committee E47
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Significance and Use
This test method is intended to permit the determination of a no observed effect level and the toxic effects associated with the repeated oral exposure to a substance for a period of 90 days. This subchronic test is not capable of determining toxic effects requiring an extended latency period to develop (for example, carcinogenicity and life shortening). It will provide information on target organs, the possibilities of accumulation, and can be used in selecting dosage levels for chronic studies and for establishing safety criteria for human exposure. It provides information on potential human health hazards likely to arise from repeated exposure over a limited period of time.
Scope
1.1 This test method has been designed to examine the subchronic oral toxicity of a test substance during a 90-day period of continuous oral exposure to rats (Rattus norvegicus) following initial acute toxicity tests.
1.2 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only.
1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
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